The revival of economic life in Tyumen province began only in 1923, when the economic mechanism of previous years was finally replaced by the exact opposite. By this time, the structural restructuring of industry had been completed, monetary wages had been restored, and equalization had been eliminated. By the end of the 1920s, it was possible to overcome the devastation in industry.

During collectivization in the Trans-Urals, 31 thousand peasant farms were expelled from other republics and regions, which amounted to about 150 thousand people. With their labor, about 150 villages were built in remote, uninhabited places.

In 1934, the Ural Region was abolished. At the same time, a significant part of the Trans-Urals became part of the Ob-Irtysh region with its center in Tyumen. However, the new entity existed only until the beginning of 1935, when it was deemed advisable to include the region in the Omsk region.

A major event in the history of the region was the formation of the Tyumen region on August 14, 1944. The new region was the largest in the country. Its area was 1,435.2 thousand square kilometers, which accounted for more than 8% of the territory of the RSFSR.

The formation of the Tyumen Region basically completed a twenty-year period of continuous changes in the administrative and territorial borders in this part of Western Siberia. Started in the early twenties with the liquidation of the Tyumen province, they were primarily caused by political motives and did not meet the needs of the economic and cultural life of the territory, as a historically unified region of Russia. As a result, during the 20−30s, there was a weakening and even a rupture of centuries-old ties, which negatively affected the development of the region, especially its northern regions.

Immediately after the publication of the decree on the formation of the Tyumen region, the formation of regional authorities and management began. The Regional Council of Workers' Deputies was headed by K. F. Koshelev. Sessions of district, city, and district councils were held in the fall of 1944 and spring of 1945.

Huge investments have significantly changed the industrial appearance of the region. In 1959−1965, about 800,000 square meters of housing were built, large enterprises in Tyumen, dozens of forestry enterprises and woodworking enterprises were commissioned, 22 oil and 23 gas fields were discovered. In 1965, 3.2 million kWh of electricity, 164 batteries, 5.5 thousand pairs of shoes, 266 meters of carpets, 2.7 thousand tons of oil were produced in one day in the Tyumen region, 5.8 thousand passengers were transported.

With the establishment of the Tyumen Region in 1944, the Shopping Area was chosen for the construction of administrative buildings. The square was designed by the chief architect of Tyumen, P. A. Grinenko. Flower beds and alleys were laid out on the square, buildings of the Ministry of Internal Affairs and the Ministry of State Security (1948−51) and residential buildings for officials of regional organizations were built at the intersections of Volodarsky and Vodopodnaya streets, as well as on the 8 March Street.

In 1950, a post office was built. In 1953, the building of the engineering college was erected here, and in 1956, the building of the regional committee of the CPSU, which now houses the regional administration. By the early 1960s, residential buildings were built around the Central Square, and by 1964, the building of the House of Soviets (the Regional Executive Committee). In the 1950s, the trade on the square was closed, and it was no longer called Trading: the name "Regional Committee" was used. The bronze monument to Lenin was erected on October 27, 1979. Finally, the square was renamed Central in January 1986, when preparations were underway for the 400th anniversary of Tyumen.

In 1955, a 62-meter-high television tower was erected next to the Post Office, from which television broadcasts of Tyumen television began in 1957.