Back in the second half of the 19th century, factory production originated in the southern counties of the province. The appearance of factories marked the beginning of the technical restructuring of industry. In the first decade of the 20th century alone, the labor force at the enterprises of the province increased threefold. In 1908, they had 126 steam engines with a capacity of 2,262 hp. By that time, the factory industry accounted for about half of all industrial output recorded by official statistics.

Cloth-weaving and paper production occupied an important place in the Tyumen factory industry. In 1875, the Yadryshnikov cloth factory was founded, and in the late 80s, the cloth factory of the Karyakin and Andreev trading house was founded. In 1889, in the village of Zavado-Uspenskiy, Chervishevskaya volost, near Tyumen, the Siberian Trading partnership Al. Shcherbakov and Co. opened a stationery factory equipped with five steam engines. In the late 90s, the factory employed 375 workers. It was the largest paper industry enterprise in Siberia.

Tobolsk province was one of the few outside the Urals where there were large metalworking and machine-building enterprises. The N. D. Masharov Iron Foundry was founded in 1900 in Tyumen. 220 workers were employed at this plant. His workshops produced cast iron, turbines for mills, enameled dishes, nails.

By the end of the 20s of the twentieth century, it was possible to overcome the devastation in industry that arose during the Civil War. Enterprises and artisanal workshops of the region produced consumer goods, building materials, agricultural implements, and small river vessels.

In the early 1930s, Tyumen remained the main industrial center of the Trans‑Urals. Industrial products were produced by the plants "Mechanic", "Ugolnik", the plant "Flame", sawmills, and food enterprises. A plywood factory, a woodworking plant, and a factory named after him were built. Chelyuskintsev, a new power plant, various workshops.

The industrial appearance of Tobolsk has changed somewhat. On the eve of the war, there were 39 enterprises in the ancient Siberian city, including those of allied importance. This is the Obtrest shipyard and a biofactory that produced vaccines and biologics. There were food industry enterprises in the city, as well as sewing, woodworking, locksmith workshops and several artels of commercial cooperation. The trusts of the fishing industry and the Main Northern Sea Route are located here.

A milk powder factory and a sawmill were built in small Yalutorovsk.

Since the beginning of the war, 22 enterprises were evacuated to Tyumen in 1941. Currently well-known factories were created on their basis: battery, ATA, instrument-making, construction machinery, chemical and pharmaceutical. The Taganrog motorcycle factory is located in the premises of the former brewery. The evacuated equipment was used in the construction of the Tazovsky and Surgut fish canneries, and the Ishim trailer factory.

Siberia during the war years was characterized by an unprecedented outflow of the rural population into industry. An even greater number of rural workers went to the front. By the beginning of 1944, the total number of able-bodied collective farmers had decreased by 40.8% compared to the pre-war period. 92% of the car fleet was sent to the front and industry.

The women of the northern national districts became fishermen, loggers and hunters.

In 1947, the industry of the region as a whole fulfilled the annual task and switched to mass production of new types of civilian products. The Mekhanik plant, instead of hulls for machines, began to produce three—sheathed finders, edging machines and wagon ramps; the Shipyard, instead of torpedo boats, produced tugboats, lighters, and steel barges; Stroymashin, instead of mines, produced concrete mixers.

Tyumen Motor Plant was founded in 1963. The factory made engines for deck‑based aircraft, rocket engines for air defense systems and cruise missiles, and engines for mass-produced An-24 aircraft.

The history of the Tyumen scales dates back to 1959. In the very first year, the local instrument-making plant produced 2,160 copies.